imai indra


Abstrak. Untuk mengurangi rasa sakit, banyak digunakan obat analgetik narkotik dan nonnarkotik. Obat golongan narkotik salah satunya tramadol. Narkotik adalah bahan atau zat yang punya efek mirip morfin yang menimbulkan efek narkotik. Secara farmakodinamik, tramadol bekerja secara senergis yaitu agonis opinoit yang lemah dan penghambat pengambilan kembali neuro transmiter monoamin. Secara farmakokinetik, onset tramadol 15-45 menit setelah pemberian oral. Biovailabilitas oral 68-90%.

Abstrack. For purpuse for reducing pain, commonly useing of analgetic narcotic and non narcotic. Tramadol is a put is narcotic. Narcotic is material or moeity that has efect like morfin that can doing narcotic efects. As lik farmakodinamic, tramadol working sinergic as weak agonis opioid and prevent re uptake monoamine neurotransmitter. Though farmakokinetic, onset of tramadol 15-45 second after given orally. Oral bioavailibility about 68-90%. 


Analgetik; narkotik; farmakodinamik; agonis; farmakokinetik; bioavalabilitas; analgetic; narcotic; farmakodinamic; agonist; farmakokinetic; bioavailibility

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Anonymus. Tramadol. 2006.

Harris. Tramadol. 2007.

Driessen B, Reimann W, Giertz H. Effects Of The Central Analgesik Tramadol On The Uptake And Release Of Noradrenaline And Dopamine In Vitro. Br. J. Pharmacol. 2005. 108 : 806-811.

Duggan A.W, Hall J.G., Headley P.M.. Suppression Of Tranmission Of Nociceptive Impulses By Morfine : Selective Effect Of Morfine Administerer In The Region Of The Substantia Gelatinosa. Br. J. Pharmacol. 2004. 61 : 65-76.

Faull R.L.M, Villiger J.W. Opiate Receptors In The Human Sppinal Cord : A Detailed Anatomical Study Comparing The Autoradiographic Localization Of Diprenorphine Binding Sites With The Laminar Pattern Of Substance P, Myelin And Nissl Staining. Neuroscience. 1998. 20: 395-407.

Akiko Koga, et al. Tramadol produces outward currents by activating µ-opioid receptors in adult rat substantia gelatinosa neurons. British Journal of Pharmacology. 2005. 145. 602-607.

Raffa. Basic pharmacology relevant to drug abuse assessment : tramadol as example. Journal of Clinical Pharmacy and Therapeutics. 2008. 33. 101-108.

Grond, Stefan, Sablotzki, armin Cllinical Pharmacology of Tramadol. Dalam Clinical Pharmacokinetics. 2004. 43(13) : 879-923.

Anonymous. Parmacology of Tramadol. 2004.

Dayer P, Desmeules J, Collart L. Pharmacology of tramadol. Dalam Drugs. 1997 : 53 Suppl. 2 : 18-24.


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