HUBUNGAN ANTARA AKTIVASI MAKROFAG DENGAN KADAR INTERLEUKIN-6 DAN ANTIBODI TERHADAP Salmonella typhi PADA MENCIT (Relationship between the Macrophage Activity with Interleukin-6 Levels and Titers of Antibodies against Salmonella typhi)

I Nengah Kerta Besung, Nyoman Mantik Astawa, Ketut Suata, Ni Ketut Suwiti


This study aims to determine the relationships between macrophage activities and interleukin-6 (IL-6 levels), and titer antibody to Salmonella typhi (S. typhi). A total of 32 mice were infected intraperitoneally with 105 cells/ml of S. typhi. The activities of macrophages were observed a day after the infection, while the observations of the levels of IL-6 and titer antibody employing enzyme-linked immunosorbent assay (ELISA) method were conducted after one and two weeks of infection. The results showed that the average activities of macrophages after infected by S. typhi was 77.84±11.23 sel, and the levels of IL-6 and antibody titers were higher (159.55±90.11 pg and 56.87±23.32 IU respectively). The macrophage activities were significantly increased (P<0.01) with increasing the level of IL-6 to Y= -0.317x2 + 0.0033x2 +494.09 with the relatedness (r)= 0.89 and the antibody titers to Y= -0.020x2 + 0.00031x + 29.083 with the relatedness (r)= 0.95.

Key words: macrophage activity, IL-6, antibody titers, Salmonella typhi

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