DEVELOPMENT OF THE CORTICAL AND MEDULLARY CELLS OF ADRENAL GLAND IN THE LONG-TAILED MACAQUE (Macaca fascicularis) DURING PRE- AND POSTNATAL PERIOD

Danang Dwi Cahyadi, Nurhidayat Nurhidayat, Supratikno Supratikno, Savitri Novelina, Chairun Nisa', Heru Setijanto

Abstract


The study aimed to analyze the dynamics of the development of cortical and medullary cells of adrenal gland in the long-tailed macaque (Macaca fascicularis) during pre- and postnatal period. The samples of adrenal glands were taken from 5 fetuses aged 70, 85, 100, 120, and 150 days of gestation, a newborn aged 10, and an infant aged 105 days old. The samples of the adrenal glands were stained with hematoxylin-eosin and Masson trichrome (Goldner’s modification). The results showed that the fetal adrenal cortex consisted of a definitive and fetal zones, but in the late gestation (fetus aged 150 days of gestation), the transitional zone appeared between both zones. At the postnatal period, the definitive zone changed to glomerulosa zone, while the outer cells of the transitional zone changed to fasciculata zone which radially arranged. The results indicated that the fetal zone was present until birth and it will disappear gradually after birth. The medullary cells were found at the fetal stages as an irregular structure of small islands of chromaffin cells in the fetal zone. This structure migrated slowly to the center of the adrenal glands. The characteristics of mature chromaffin cells were found in the adrenal glands at postnatal period. In conclusion, the cortex adrenal of the newborn of long-tailed macaque consisted of zona glomerulosa, zona fasciculata, zona transitional, and the remaining fetal zone that has dissapeared gradually after birth.

Keywords


adrenal gland; cortical cells; development; medullary cells; monkey

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Allmendinger, A., E. Stoeckel, M. Saarma, K. Unsicker, and K. Huber. 2003. Development of adrenal chromaffin cells is largely normal in mice lacking the receptor tyrosine kinase c-Ret. Mech. Dev. 120:299-304. https://doi.org/10.1016/S0925-4773(02)00455-0.

Coulter, C.L. 2004. Functional biology of the primate fetal adrenal gland: advances in technology provide new insight. Clin. Exp. Pharmacol. Physiol. 31:475–484. https://doi.org/10.1111/j.1440-1681.2004.04031.x.

Dumitrescu, A., G.W. Aberdeen, G.J. Pepe, and E.D. Albrecht. 2007. Developmental expression of cell cycle regulators in the baboon fetal adrenal gland. J. Endocrinol. 192:237–247. https://doi.org/10.1677/joe.1.06769.

Fortman, J.D., A.H. Terry, and B. Taylor Bennet. 2002. The Laboratory Nonhuman Primate. CRC Press, Florida.

Friedrich, M. 1996. Influence of exogenous and endogenous ACTH on adrenal cortex activity in calves during the early postnatal period. Br. Vet. J. 152:315–320.

Frödin, M. and S. Gammeltoft. 1994. Insulin-like growth factors act synergistically with basic fibroblast growth factor and nerve growth factor to promote chromaffin cell proliferation. Proc. Natl. Acad. Sci. USA 91(5):1771-1775. https://doi.org/10.1073/pnas.91.5.1771.

Huber, K. 2006. The sympathoadrenal cell lineage: specification, diversification, and new perspectives. Dev. Biol. 298:335-343. https://doi.org/ 10.1016/j.ydbio.2006.07.010.

Ishimoto, H. and R.B. Jaffe. 2011. Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr. Rev. 32:317–355. https://doi.org/10.1210/er.2010-0001.

Iskandriati, D. and J. Pamungkas. 2008. Skrining beberapa patogen penting untuk menghasilkan satwa primata sebagai hewan laboratorium. Proceeding of KIVNAS 2008. Bogor, Indonesia.

Kempná, P. and C.E. Flück. 2007. Adrenal gland development dan defects. Best Pract. Res. Clin. Endocrinol. Metab. 1(22):77-93. https://doi.org/10.1016/j.beem.2007.07.008.

Kmieć, B.L. and D. Kaczmarczyk. 2004. The cellular composition of the adrenal medulla of sexually mature guinea pigs. Folia Morphol. 63(1):75-78.

Lalli, E. 2010. Adrenal cortex ontogenesis. Best Pract. Res. Clin. Endocrinol. Metab. 24:853-864. https://doi.org/10.1016/j.beem.2010.10.009.

Leavitt, M.G., E.G. Albrecht, and G.J. Pepe. 1999. Development of the baboon fetal adrenal gland: Regulation of the ontogenesis of the definitive and transitional zones by adrenocorticotropin. J. Clin. Endocrinol. Metab. 10(28):3831-3835.

Lin, L. and J.C. Achermann. 2004. The adrenal. Horm. Res. 62(suppl.3):22-29. https://doi.org/10.1159/000080495.

Lohr, J., P. Gut, N. Karch, K. Unsicker, and K. Huber. 2006. Development of chromaffin cells in Sf1 heterozygous mice. Cell Tissue Res. 325:437–444. https://doi.org/10.1007/s00441-006-0213-5.

McNulty, W.P., M.J. Novy, and S.W. Walsh. 1981. Fetal and postnatal development of adrenal glands in Macaca mulatta. Biol. Reprod. 25:1079-1089.

Mesiano, S. and R.B. Jaffe. 1997. Developmental and functional biology of the primate fetal adrenal cortex. Endocrinol. Rev. 18:378–403. https://doi.org/10.1210/edrv.18.3.0304.

Patten, B.M.. 1948. Embryology of the Pig. 3rd. McGraw-Hill, New York.

Pangestiningsih, T.W., A. Hendrickson, K. Sigit, D. Sajuthi, Nurhidayat, and D.M. Bowden. 2009. Development of the area postrema: an immunohistochemical study in the macaque. Brain Res. 1280:23-32. https://doi.org/ 10.1016/j.brainres.2009.05.028.

Pignatti, E., S. Leng, D.L. Carlone, and D.T. Breault. 2017. Regulation of zonation and homeostasis in the adrenal cortex. Mol. Cell. Endocrinol. 441:146-155. https://doi.org/10.1016/j.mce.2016.09.003.

Pryce, C.R., R. Palme, and J. Feldon. 2002. Development of pituitary-adrenal endocrine function in the marmoset monkey: infant hypercortisolism is the norm. J. Clin. Endocrinol. Metab. 87(2):691–699. https://doi.org/10.1210/jcem.87.2.8244.

Sirianni, R., K.S. Rehman, B.R. Carr, C.R. Parker, and W.E. Rainey. 2005. Corticotropin- releasing hormone directly stimulates cortisol and the cortisol biosynthetic pathway in human fetal adrenal cells. J. Clin. Endocrinol. Metab. 90(1):279–285. https://doi.org/10.1210/jc.2004-0865.

Scheys, J.O., J.H. Heaton, and G.D. Hammer. 2011. Evidence of adrenal failure in aging Dax1-deficient mice. Endocrinology 152(9):3430–3439. https://doi.org/ 10.1210/en.2010-0986.

Turner, C.D. and J.T. Bagnara. 1976. General Endocrinology. WB Saunders, Philadelphia.

Zhou, H., J. Aziza, J.C. Sol, M. Courtade-Saїdi, S. Chatelin, C. Evra, O. Parant, Y. Lazorthes, and S. Jozan. 2006. Cell therapy of pain: characterization of human fetal chromaffin cells at early adrenal medulla development. Exp. Neurol. 198:370-381. https://doi.org/10.1016/j.expneurol.2005.12.012.




DOI: https://doi.org/10.21157/j.ked.hewan.v13i1.12044

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