THE POTENTIAL EFFECT OF RED DRAGON FRUIT (Hylocereus polyrhizus) PEEL ETHANOL EXTRACT ON ENDOMETRIOSIS PROGRESSIVITY IN ENDOMETRIOSIS MICE

Anindya Hapsari, Yanuar Eka Pujiastutik

Abstract


The aim of this study was to know the effect of red dragon fruit (Hylocereus polyrhizus) peel ethanol extract at dose of 0.25, 0.5, and 1 mg/g
bw on endometriosis progressivity, signed by granuloma, on mouse model of endometriosis. Twenty five female mice were used as samples and
divided into 5 groups: 1 positive control, 1 negative control, and 3 treatment groups. Positive control and treatment groups were induced as model
of endometriosis for 14 days. The next 14 days, placebo was given to both control groups, while red dragon fruit peel ethanol extract at dose of
0.25, 0.5, and 1 mg/g bw were given to mice in treatment groups as much as 0.2 mL/25 g bw/day orally. Endometriotic lesion was examined.
Result showed that there were significantly differences on granuloma among control groups and treatment groups. The conclusion was red
dragon fruit peel ethanol extract could inhibit endometriosis progressivity, signed by granuloma, on mouse model of endometriosis.


Keywords


endometriosis progressivity; granuloma; red dragon fruit peel ethanol extract

Full Text:

PDF


DOI: https://doi.org/10.21157/j.ked.hewan.v12i2.10497

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 by author and J. Ked. Hewan

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Editorial Office

Jurnal Kedokteran Hewan (Indonesian Journal of Veterinary Sciences)

Faculty of Veterinary Medicine Syiah Kuala University
Jl. Tgk. Hasan Krueng Kalee No. 4, Kampus FKH Unsyiah Darussalam
Banda Aceh 23111, Indonesia
Phone/Fax. +62-651-7551536, CP: +6285260153935; +6281362693330
e-mail: jkh@unsyiah.ac.id; jurnal_khusk@yahoo. 

  

p-ISSN: 1978-225X e-ISSN: 2502-5600


Creative Commons License
J Ked Hewan
is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.